What Neuroinflammation Is Not
The inflammation which is present in joint or muscle diseases such as rheumatoid arthritis or fibromyalgia is not the same as neuroinflammation inside the CNS. Outside the CNS inflammation is caused by lymphocytes, but inside the CNS it is caused by microglia.
A special class of treatment agents known as microglia or neuroinflammatory suppressors cross the blood brain barrier and enter spinal fluid to control the microglial cell and reduce neuroinflammation. Standard, common inflammatory agents such as naprosyn and ibuprofen as well as the biologics are ineffective in reducing neuroinflammation. Clinical protocols for treatment of neuroinflammation are in their early stage, but they are already providing disease regression, enhanced pain relief, less suffering, and reduction in the use of symptomatic drugs such as opioids.
Major causes of chronic severe intractable pain that becomes centralized and develops neuroinflammation:
- Arachnoiditis: Lumbar and cervical
- Reflex sympathetic dystrophy (RSD) sometimes called complex regional pain syndrome (CRPS)
- Genetic connective tissue and metabolic disorders (Ehlers-Danlos, Marfans, Porphyria, sickle cell, others)
- Peritoneal adhesions with abdominal/pelvic neuropathies
- Post-viral encephalopathy/myopathy
- Peripheral neuropathy
- Lyme disease
- Traumatic brain injury
- Autoimmune disorders
Three Components of Neuroinflammation and Centralized Pain Treatment